SHMT1 1420 and MTHFR 677 variants are associated with rectal but not colon cancer.

ABSTRACT:

Background

Association between rectal or colon cancer risk and serine hydroxymethyltransferase 1 (SHMT1) C1420T or methylenetetrahydrofolate reductase (MTHFR) C677T polymorphisms was assessed. The serum total homocysteine (HCY), marker of folate metabolism was also investigated.

Methods

The SHMT1 and MTHFR genotypes were determined by real-time PCR and PCR-RFLP, respectively in 476 patients with rectal, 479 patients with colon cancer and in 461 and 478, respective controls matched for age and sex. Homocysteine levels were determined by HPLC kit. The association between polymorphisms and cancer risk was evaluated by logistic regression analysis adjusted for age, sex and body mass index. The population stratification bias was also estimated.

Results

There was no associa

SUBMITTER: Komlosi V 

PROVIDER: S-EPMC2958941 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature