LATS2 is de-methylated and overexpressed in nasopharyngeal carcinoma and predicts poor prognosis.

ABSTRACT:

Background

LATS2, which encodes a novel serine/threonine kinase, is known to be important in centrosome duplication and in the maintenance of genomic stability. Recently, a potential role for LATS2 in cancer has been reported. In breast cancer and acute lymphoblastic leukemia (ALL), LATS2 mRNA is downregulated and has been suggested to be a tumor suppressor. However, the role of LATS2 in nasopharyngeal carcinoma has not been investigated. In this study, we aimed to investigate the expression pattern of LATS2 and its clinicopathological involvement in nasopharyngeal carcinoma to understand its effect on cell survival.

Methods

Using quantitative real time PCR and immunoblotting, the expression of LATS2 was detected in nasopharyngeal carcinoma cell lines and in the immortalized

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC2958949 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature