Clinical significance of Polycomb gene expression in brain tumors.
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ABSTRACT:
SUBMITTER: Crea F
PROVIDER: S-EPMC2958980 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
Publications
Clinical significance of Polycomb gene expression in brain tumors.
Crea Francesco F Hurt Elaine M EM Farrar William L WL
Molecular cancer 20100930
Polycomb group (PcG) proteins are crucial for neural cancer stem cell (NCSC) self-renewal. However, the relative expression levels of PcG genes in different subtypes of brain tumors, their prognostic role and their effects on cellular pathways have not been investigated. For this purpose, we queried the Oncomine database and found that 4 PcG genes (EZH2, RBBP7, SUZ12, YY1) are specifically expressed in brain tumors. EZH2 expression increases with tumor grade in adult and pediatric brain tumors, ...[more]
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