Association of phospholipase A2 receptor 1 polymorphisms with idiopathic membranous nephropathy in Chinese patients in Taiwan.

ABSTRACT:

Background

Idiopathic membranous nephropathy (IMN) is one of the most common forms of autoimmune nephritic syndrome in adults. The purpose of this study is to evaluate whether polymorphisms of PLA2R1 affect the development of IMN.

Methods

Taiwanese-Chinese individuals (129 patients with IMN and 106 healthy controls) were enrolled in this study. The selected single nucleotide polymorphisms (SNPs) in PLA2R1 were genotyped by real-time polymerase chain reaction using TaqMan fluorescent probes, and were further confirmed by polymerase chain reaction-restriction fragment length polymorphism. The roles of the SNPs in disease progression were analyzed.

Results

Genotype distribution was significantly different between patients with IMN and controls for PLA2R1 SNP rs35771982 (

SUBMITTER: Liu YH 

PROVIDER: S-EPMC2959017 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature