The humoral response to Plasmodium falciparum VarO rosetting variant and its association with protection against malaria in Beninese children.

ABSTRACT:

Background

The capacity of Plasmodium falciparum-infected erythrocytes to bind uninfected erythrocytes (rosetting) is associated with severe malaria in African children. Rosetting is mediated by a subset of the variant surface antigens PfEMP1 targeted by protective antibody responses. Analysis of the response to rosette-forming parasites and their PfEMP1 adhesive domains is essential for understanding the acquisition of protection against severe malaria. To this end, the antibody response to a rosetting variant was analysed in children recruited with severe or uncomplicated malaria or asymptomatic P. falciparum infection.

Methods

Serum was collected from Beninese children with severe malaria, uncomplicated malaria or P. falciparum asymptomatic infection (N = 65, 37 and 52, r

SUBMITTER: Vigan-Womas I 

PROVIDER: S-EPMC2959068 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature