Relations of biomarkers of extracellular matrix remodeling to incident cardiovascular events and mortality.

ABSTRACT:

Objective

To evaluate if biomarkers reflecting left ventricular/vascular extracellular matrix remodeling are associated with cardiovascular disease (CVD) and death in the community.

Methods and results

In 922 Framingham Study participants (mean age, 58 years; 56% women), we related circulating concentrations of matrix metalloproteinase-9 (binary variable: detectable versus undetectable), log of tissue inhibitor of matrix metalloproteinase-1, and log of procollagen type III aminoterminal peptide (PIIINP) to incident CVD and death. On follow-up (mean, 9.9 years), 51 deaths and 81 CVD events occurred. Each SD increment of log of tissue inhibitor of matrix metalloproteinase-1 and log-PIIINP was associated with multivariable-adjusted hazards ratios of 1.72 (95% CI, 1.30 to 2.27)

SUBMITTER: Velagaleti RS 

PROVIDER: S-EPMC2959140 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature