6β-Acetamido-5α-hydroxy-cholestan-3β-yl acetate.

ABSTRACT: The title steroid, C(31)H(53)NO(4), was prepared from the corresponding 5α,6α-epoxy-cholestane. The conformation of the six-membered rings is close to a chair form, while the five-membered ring adopts a twist conformation. The hydroxyl and acetamide groups are in axial positions. The nucleophilic species bound to the steroid nucleus at position 6 by the β-face, whereas the hydroxyl group at position 5 has α-orientation. All rings are trans-fused. The crystal packing shows that the mol-ecules related by twofold symmetry exist as O-H⋯O hydrogen-bonded dimers.

SUBMITTER: Pinto RM 

PROVIDER: S-EPMC2959794 | biostudies-literature | 2008 Nov

REPOSITORIES: biostudies-literature