Transcription of quorum-sensing system genes in clinical and environmental isolates of Pseudomonas aeruginosa.

ABSTRACT: Quorum sensing (QS)-based transcriptional responses in Pseudomonas aeruginosa have been defined on the basis of increases in transcript levels of QS-controlled genes such as lasB and aprA following the hierarchical transcriptional increases of central controllers such as the lasR gene. These increases occur at high bacterial concentrations such as early-stationary-phase growth in vitro. However, the extent to which the increases occur in a variety of clinical and environmental isolates has not been determined nor is there extensive information on allelic variation in lasR genes. An analysis of the sequences of the lasR gene among 66 clinical and environmental isolates showed that 81% have a sequence either identical to that of strain PAO1 or with a silent mutation, 15% have nucleotide chan

SUBMITTER: Cabrol S 

PROVIDER: S-EPMC296264 | biostudies-literature | 2003 Dec

REPOSITORIES: biostudies-literature