Serotonin polymorphisms and posttraumatic stress disorder in a trauma exposed African American population.

ABSTRACT:

Background

Genetic polymorphisms that influence serotonin (5-hydroxytryptamine, 5HT) neurotransmission are candidates for contributing to susceptibility to posttraumatic stress disorder (PTSD). The objective of our study was to determine if a variable length polymorphism for the promoter regions of the 5HT transporter (5HTTLPR), and/or a substitution polymorphism in the promoter region for the 5HT2A receptor, would be associated with PTSD in a trauma exposed population of adult African-Americans.

Methods

Using a case control design, 118 participants recruited from the primary care clinics and the campus of a historically black university who met inclusion criteria including trauma exposure provided blood samples for genomic DNA. PTSD criteria were determined by the Clinician

SUBMITTER: Mellman TA 

PROVIDER: S-EPMC2963151 | biostudies-literature | 2009

REPOSITORIES: biostudies-literature