DsbA-L alleviates endoplasmic reticulum stress-induced adiponectin downregulation.

ABSTRACT:

Objective

Obesity impairs adiponectin expression, assembly, and secretion, yet the underlying mechanisms remain elusive. The aims of this study were 1) to determine the molecular mechanisms by which obesity impairs adiponectin multimerization and stability, and 2) to determine the potential role of disulfide-bond-A oxidoreductase-like protein (DsbA-L), a recently identified adiponectin interactive protein that promotes adiponectin multimerization and stability in obesity-induced endoplasmic reticulum (ER) stress and adiponectin downregulation.

Research design and methods

Tauroursodeoxycholic acid (TUDCA), a chemical chaperone that alleviates ER stress, was used to study the mechanism underlying obesity-induced adiponectin downregulation in db/db mice, high-fat diet-induced o

SUBMITTER: Zhou L 

PROVIDER: S-EPMC2963539 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature