Warfarin dosing in patients with impaired kidney function.

ABSTRACT:

Background

In patients with kidney impairment, warfarin, a drug metabolized primarily by the cytochrome P-450 system, is initiated at similar doses and managed similarly as in the general medical population. Unfortunately, few data exist to guide dose adjustment in patients with decreased kidney function. Here, we determine the degree of warfarin dose reduction associated with kidney impairment and make recommendations for warfarin dosing.

Study design

Cross-sectional analysis.

Setting & participants

Long-term warfarin users followed up at anticoagulation clinics (n = 980); 708 participants from the University of Alabama (UAB) and 272 participants from the University of Chicago (UIC).

Predictor

No/mild (estimated glomerular filtration rate [eGFR] ≥ 60 mL/min/1.

SUBMITTER: Limdi NA 

PROVIDER: S-EPMC2963672 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature