Comparative analysis of full-length genomic sequences of 10 dengue serotype 1 viruses associated with different genotypes, epidemics, and disease severity isolated in Thailand over 22 years.

ABSTRACT: Comparative sequence analysis was performed on the full-length genomic sequences of 10 representative dengue virus serotype 1 (DENV-1) strains sampled from patients at Children's Hospital, Bangkok, Thailand over a 22-year period, which represented different epidemics, disease severity, and sampling time. The results showed remarkable inter-genotypic variation between predominant and non-predominant genotypes and genotype-specific amino acids and nucleotides throughout the entire viral genome except for the 5'-non-translated region. The frequency of intra-genotypic variation was correlated with dengue transmission rate and sampling time. The 5'-non-translated region of all 10 viruses was highly conserved for predominant and non-predominant genotypes and NS2B was the most conserved protein.

SUBMITTER: Tang Y 

PROVIDER: S-EPMC2963987 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature