HAGE, a cancer/testis antigen expressed at the protein level in a variety of cancers.

ABSTRACT: The search for novel tumour antigens that are either uniquely expressed or over-expressed in a wide variety of tumours is still ongoing. Because of their expression in a broad spectrum of cancers and limited expression in normal tissues, cancer/testis antigens are considered to be potentially reliable targets for immunotherapy of cancer in general. The helicase antigen HAGE has been identified as a cancer/testis antigen. However, little is known about its expression in normal and cancer tissues. Using a newly developed antibody against HAGE, specific staining of its expression by immunohistochemistry was validated and optimised on murine tumours transfected to express the HAGE protein. The antibody was subsequently used to determine HAGE expression in normal human and cancer tissue microar

SUBMITTER: Mathieu MG 

PROVIDER: S-EPMC2964012 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature