A comprehensive molecular interaction map of the budding yeast cell cycle.

ABSTRACT: With the accumulation of data on complex molecular machineries coordinating cell-cycle dynamics, coupled with its central function in disease patho-physiologies, it is becoming increasingly important to collate the disparate knowledge sources into a comprehensive molecular network amenable to systems-level analyses. In this work, we present a comprehensive map of the budding yeast cell-cycle, curating reactions from ∼600 original papers. Toward leveraging the map as a framework to explore the underlying network architecture, we abstract the molecular components into three planes--signaling, cell-cycle core and structural planes. The planar view together with topological analyses facilitates network-centric identification of functions and control mechanisms. Further, we perform a comparativ

SUBMITTER: Kaizu K 

PROVIDER: S-EPMC2964125 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature