PLCγ-activated signalling is essential for TrkB mediated sensory neuron structural plasticity.

ABSTRACT:

Background

The vestibular system provides the primary input of our sense of balance and spatial orientation. Dysfunction of the vestibular system can severely affect a person's quality of life. Therefore, understanding the molecular basis of vestibular neuron survival, maintenance, and innervation of the target sensory epithelia is fundamental.

Results

Here we report that a point mutation at the phospholipase Cγ (PLCγ) docking site in the mouse neurotrophin tyrosine kinase receptor TrkB (Ntrk2) specifically impairs fiber guidance inside the vestibular sensory epithelia, but has limited effects on the survival of vestibular sensory neurons and growth of afferent processes toward the sensory epithelia. We also show that expression of the TRPC3 cation calcium channel, whose act

SUBMITTER: Sciarretta C 

PROVIDER: S-EPMC2964534 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature