Interpreting scores on multiple sclerosis-specific patient reported outcome measures (the PRIMUS and U-FIS).

ABSTRACT:

Background

The PRIMUS is a Multiple Sclerosis (MS)-specific suite of outcome measures including assessments of QoL (PRIMUS QoL, scored 0-22) and activity limitations (PRIMUS Activities, scored 0-30). The U-FIS is a measure of fatigue impact (scored 0-66). These measures have been fully validated previously using an MS sample with mixed diagnoses. The aim of the present study was to validate the measures further in a specifically Relapse Remitting MS (RRMS) sample and to provide preliminary evidence of the responder definitions (RD; also known as minimal important difference) for these instruments.

Methods

Data were derived from a multi-country efficacy trial of MS patients with assessments at baseline and 12 months. Baseline data were used to assess the internal reliability

SUBMITTER: Twiss J 

PROVIDER: S-EPMC2964544 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature