Predicting enzyme targets for cancer drugs by profiling human metabolic reactions in NCI-60 cell lines.

ABSTRACT:

Background

Drugs can influence the whole metabolic system by targeting enzymes which catalyze metabolic reactions. The existence of interactions between drugs and metabolic reactions suggests a potential way to discover drug targets.

Results

In this paper, we present a computational method to predict new targets for approved anti-cancer drugs by exploring drug-reaction interactions. We construct a Drug-Reaction Network to provide a global view of drug-reaction interactions and drug-pathway interactions. The recent reconstruction of the human metabolic network and development of flux analysis approaches make it possible to predict each metabolic reaction's cell line-specific flux state based on the cell line-specific gene expressions. We first profile each reaction by its flu

SUBMITTER: Li L 

PROVIDER: S-EPMC2964682 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature