Evolutionary history of the poly(ADP-ribose) polymerase gene family in eukaryotes.

ABSTRACT:

Background

The poly(ADP-ribose) polymerase (PARP) superfamily was originally identified as enzymes that catalyze the attachment of ADP-ribose subunits to target proteins using NAD+ as a substrate. The family is characterized by the catalytic site, termed the PARP signature. While these proteins can be found in a range of eukaryotes, they have been best studied in mammals. In these organisms, PARPs have key functions in DNA repair, genome integrity and epigenetic regulation. More recently it has been found that proteins within the PARP superfamily have altered catalytic sites, and have mono(ADP-ribose) transferase (mART) activity or are enzymatically inactive. These findings suggest that the PARP signature has a broader range of functions that initially predicted. In this study, we

SUBMITTER: Citarelli M 

PROVIDER: S-EPMC2964712 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature