Mutational dynamics of murine angiogenin duplicates.

ABSTRACT:

Background

Angiogenin (Ang) is a protein involved in angiogenesis by inducing the formation of blood vessels. The biomedical importance of this protein has come from findings linking mutations in Ang to cancer progression and neurodegenerative diseases. These findings highlight the evolutionary constrain on Ang amino acid sequence. However, previous studies comparing human Angiogenin with homologs from other phylogenetically related organisms have led to the conclusion that Ang presents a striking variability. Whether this variability has an adaptive value per se remains elusive. Understanding why many functional Ang paralogs have been preserved in mouse and rat and identifying functional divergence mutations at these copies may explain the relationship between mutations and functi

SUBMITTER: Codoner FM 

PROVIDER: S-EPMC2964713 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature