Ontology highlight
ABSTRACT:
SUBMITTER: Liu X
PROVIDER: S-EPMC2964934 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
FEBS letters 20100904 18
Deregulations of microRNA have been frequently observed in tongue squamous cell carcinoma (TSCC), but their roles in tumorigenesis are not entirely clear. Here, we reported the up-regulation of miR-24 in TSCC. MiR-24 up-regulation reduced the expression of RNA-binding protein dead end 1 (DND1). Knockdown of miR-24 led to enhanced expression of DND1. The direct targeting of miR-24 to the DND1 mRNA was predicted bioinformatically and confirmed by luciferase reporter gene assays. Furthermore, the m ...[more]