Acute depletion of activated memory B cells involves the PD-1 pathway in rapidly progressing SIV-infected macaques.

ABSTRACT: Rapid progression to AIDS is a significant problem, especially in developing countries, where the majority of HIV-infected individuals reside. As rapid disease progression is also frequently observed in SIV-infected macaques, they represent a valuable tool to investigate the pathogenesis of this condition in humans. Here, we have shown that pathogenic SIV infection in rhesus macaques resulted in a rapid depletion (as early as week 2) of activated memory B (CD21-CD27+; mBAct) cells that was strongly associated with rapid disease progression. This depletion was progressive and sustained in rapid progressors, but less severe and transient in typical progressors. Because of the rapid and sustained depletion of mBAct cells, rapid progressors failed to develop SIV-specific Ab responses, showed a

SUBMITTER: Titanji K 

PROVIDER: S-EPMC2964982 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature