A general model of codon bias due to GC mutational bias.

ABSTRACT:

Background

In spite of extensive research on the effect of mutation and selection on codon usage, a general model of codon usage bias due to mutational bias has been lacking. Because most amino acids allow synonymous GC content changing substitutions in the third codon position, the overall GC bias of a genome or genomic region is highly correlated with GC3, a measure of third position GC content. For individual amino acids as well, G/C ending codons usage generally increases with increasing GC bias and decreases with increasing AT bias. Arginine and leucine, amino acids that allow GC-changing synonymous substitutions in the first and third codon positions, have codons which may be expected to show different usage patterns.

Principal findings

In analyzing codon usage bias in

SUBMITTER: Palidwor GA 

PROVIDER: S-EPMC2965080 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature