The evolution of vertebrate tetraspanins: gene loss, retention, and massive positive selection after whole genome duplications.

ABSTRACT:

Background

The vertebrate tetraspanin family has many features which make it suitable for preserving the imprint of ancient sequence evolution and amenable for phylogenomic analysis. So we believe that an in-depth analysis of the tetraspanin evolution not only provides more complete understanding of tetraspanin biology, but offers new insights into the influence of the two rounds of whole genome duplication (2R-WGD) at the origin of vertebrates.

Results

A detailed phylogeny of vertebrate tetraspanins was constructed by using multiple lines of information, including sequence-based phylogenetics, key structural features, intron configuration and genomic synteny. In particular, a total of 38 modern tetraspanin ortholog lineages in bony vertebrates have been identified and subse

SUBMITTER: Huang S 

PROVIDER: S-EPMC2965184 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature