Chromosome 9p21 in amyotrophic lateral sclerosis in Finland: a genome-wide association study.

ABSTRACT:

Background

The genetic cause of amyotrophic lateral sclerosis (ALS) is not well understood. Finland is a well suited location for a genome-wide association study of ALS because the incidence of the disease is one of the highest in the world, and because the genetic homogeneity of the Finnish population enhances the ability to detect risk loci. We aimed to identify genetic risk factors for ALS in the Finnish population.

Methods

We did a genome-wide association study of Finnish patients with ALS and control individuals by use of Illumina genome-wide genotyping arrays. DNA was collected from patients who attended an ALS specialty clinic that receives referrals from neurologists throughout Finland. Control samples were from a population-based study of elderly Finnish individuals

SUBMITTER: Laaksovirta H 

PROVIDER: S-EPMC2965392 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature