Transmission intensity and drug resistance in malaria population dynamics: implications for climate change.

ABSTRACT: Although the spread of drug resistance and the influence of climate change on malaria are most often considered separately, these factors have the potential to interact through altered levels of transmission intensity. The influence of transmission intensity on the evolution of drug resistance has been addressed in theoretical studies from a population genetics' perspective; less is known however on how epidemiological dynamics at the population level modulates this influence. We ask from a theoretical perspective, whether population dynamics can explain non-trivial, non-monotonic, patterns of treatment failure with transmission intensity, and, if so, under what conditions. We then address the implications of warmer temperatures in an East African highland, where, as in other similar regio

SUBMITTER: Artzy-Randrup Y 

PROVIDER: S-EPMC2965653 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature