Analysis of chaperone mRNA expression in the adult mouse brain by meta analysis of the Allen Brain Atlas.

ABSTRACT: The pathology of many neurodegenerative diseases is characterized by the accumulation of misfolded and aggregated proteins in various cell types and regional substructures throughout the central and peripheral nervous systems. The accumulation of these aggregated proteins signals dysfunction of cellular protein homeostatic mechanisms such as the ubiquitin/proteasome system, autophagy, and the chaperone network. Although there are several published studies in which transcriptional profiling has been used to examine gene expression in various tissues, including tissues of neurodegenerative disease models, there has not been a report that focuses exclusively on expression of the chaperone network. In the present study, we used the Allen Brain Atlas online database to analyze chaperone express

SUBMITTER: Tebbenkamp AT 

PROVIDER: S-EPMC2965669 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature