Gene regulatory network reveals oxidative stress as the underlying molecular mechanism of type 2 diabetes and hypertension.

ABSTRACT:

Background

The prevalence of diabetes is increasing worldwide. It has been long known that increased rates of inflammatory diseases, such as obesity (OBS), hypertension (HT) and cardiovascular diseases (CVD) are highly associated with type 2 diabetes (T2D). T2D and/or OBS can develop independently, due to genetic, behavioral or lifestyle-related variables but both lead to oxidative stress generation. The underlying mechanisms by which theses complications arise and manifest together remain poorly understood. Protein-protein interactions regulate nearly every living process. Availability of high-throughput genomic data has enabled unprecedented views of gene and protein co-expression, co-regulations and interactions in cellular systems.

Methods

The present work, applied a sys

SUBMITTER: Jesmin J 

PROVIDER: S-EPMC2965702 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature