Associations between SNPs in candidate immune-relevant genes and rubella antibody levels: a multigenic assessment.

ABSTRACT:

Background

The mechanisms of immune response are structured within a highly complex regulatory system. Genetic associations with variation in the immune response to rubella vaccine have typically been assessed one locus at a time. We simultaneously assessed the associations between 726 SNPs tagging 84 candidate immune response genes and rubella-specific antibody levels. Blood samples were obtained from 714 school-aged children who had received two doses of MMR vaccine. Associations between rubella-specific antibody levels and 726 candidate tagSNPs were assessed both one SNP at a time and in a variety of multigenic analyses.

Results

Single-SNP assessments identified 4 SNPs that appeared to be univariately associated with rubella antibody levels: rs2844482 (p = 0.0002) and rs2

SUBMITTER: Pankratz VS 

PROVIDER: S-EPMC2965704 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature