Associations among GABRG1, level of response to alcohol, and drinking behaviors.

ABSTRACT:

Background

Recent studies of the genetics of alcoholism have focused on a cluster of genes encoding for gamma-aminobutyric acid (GABA(A)) receptor subunits, which is thought to play a role in the expression of addiction phenotypes. This study examined allelic associations between 2 single nucleotide polymorphisms (SNPs) of the GABRG1 gene (rs1391166 and rs1497571) and alcohol phenotypes, namely level of response to alcohol, alcohol use patterns, and alcohol-related problems.

Method

Participants were non-treatment-seeking seeking hazardous drinkers (n = 124) who provided DNA samples, participated in a face-to-face interview for level of response to alcohol, and completed a series of drinking and individual differences measures.

Results

Analyses revealed that a SNP of t

SUBMITTER: Ray LA 

PROVIDER: S-EPMC2965732 | biostudies-literature | 2009 Aug

REPOSITORIES: biostudies-literature