Actin depolymerizing factors cofilin1 and destrin are required for ureteric bud branching morphogenesis.

ABSTRACT: The actin depolymerizing factors (ADFs) play important roles in several cellular processes that require cytoskeletal rearrangements, such as cell migration, but little is known about the in vivo functions of ADFs in developmental events like branching morphogenesis. While the molecular control of ureteric bud (UB) branching during kidney development has been extensively studied, the detailed cellular events underlying this process remain poorly understood. To gain insight into the role of actin cytoskeletal dynamics during renal branching morphogenesis, we studied the functional requirements for the closely related ADFs cofilin1 (Cfl1) and destrin (Dstn) during mouse development. Either deletion of Cfl1 in UB epithelium or an inactivating mutation in Dstn has no effect on renal morphogenes

SUBMITTER: Kuure S 

PROVIDER: S-EPMC2965756 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature