Ubiquitin D is correlated with colon cancer progression and predicts recurrence for stage II-III disease after curative surgery.

ABSTRACT:

Background

Our recent study observed that the expression of ubiquitin D (UBD), a member of ubiquitin-like modifier family, was upregulated in colon cancer parenchymal cells. The present study further investigated the clinical signicance of UBD in colon cancer.

Methods

Using quantitative PCR, tissue microarray (TMA), western blot analysis and immunohistochemical stain, we evaluated UBD mRNA and protein levels in tumour tissues from patients with colon cancer at different stages and in paired adjacent normal epithelium.

Results

Immunohistochemical detection of UBD on a TMA containing 203 paired specimens showed that increased cytoplasmic UBD was signicantly associated with depth of cancer invasion, lymph node metastasis, distant metastasis, tumour histologic grade, adva

SUBMITTER: Yan DW 

PROVIDER: S-EPMC2965875 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature