Evidence that αC region is origin of low modulus, high extensibility, and strain stiffening in fibrin fibers.

ABSTRACT: Fibrin fibers form the structural scaffold of blood clots and perform the mechanical task of stemming blood flow. Several decades of investigation of fibrin fiber networks using macroscopic techniques have revealed remarkable mechanical properties. More recently, the microscopic origins of fibrin's mechanics have been probed through direct measurements on single fibrin fibers and individual fibrinogen molecules. Using a nanomanipulation system, we investigated the mechanical properties of individual fibrin fibers. The fibers were stretched with the atomic force microscope, and stress-versus-strain data was collected for fibers formed with and without ligation by the activated transglutaminase factor XIII (FXIIIa). We observed that ligation with FXIIIa nearly doubled the stiffness of the fi

SUBMITTER: Houser JR 

PROVIDER: S-EPMC2965937 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature