Mapping of genetic abnormalities of primary tumours from metastatic CRC by high-resolution SNP arrays.

ABSTRACT:

Background

For years, the genetics of metastatic colorectal cancer (CRC) have been studied using a variety of techniques. However, most of the approaches employed so far have a relatively limited resolution which hampers detailed characterization of the common recurrent chromosomal breakpoints as well as the identification of small regions carrying genetic changes and the genes involved in them.

Methodology/principal findings

Here we applied 500K SNP arrays to map the most common chromosomal lesions present at diagnosis in a series of 23 primary tumours from sporadic CRC patients who had developed liver metastasis. Overall our results confirm that the genetic profile of metastatic CRC is defined by imbalanced gains of chromosomes 7, 8q, 11q, 13q, 20q and X together with loss

SUBMITTER: Sayagues JM 

PROVIDER: S-EPMC2966422 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature