Mini review: protein-protein interactions in transcription: a fertile ground for helix mimetics.

ABSTRACT: Designed ligands that inhibit protein-protein interactions involved in gene expression are valuable as reagents for genomics research and as leads for drug discovery efforts. Selective modulation of protein-protein interactions has proven to be a daunting task for synthetic ligands; however, the last decade has seen significant advances in inhibitor design, especially for helical protein interfaces. This review discusses examples of transcriptional complexes targeted by designer helices.

SUBMITTER: Guarracino DA 

PROVIDER: S-EPMC2966508 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature