Estimation and external validation of a new prognostic model for predicting recurrence-free survival for early breast cancer patients in the UK.

ABSTRACT:

Background

We aimed to estimate and externally validate a new UK-specific prognostic model for predicting the long-term risk of a first recurrent event (local recurrence, metastatic recurrence, or second primary breast cancer) in women diagnosed with early breast cancer.

Methods

Using data on the prognostic characteristics and outcomes of 1844 women treated for early breast cancer at the Churchill Hospital in Oxford, parametric regression-based survival analysis was used to estimate a prognostic model for recurrence-free survival. The model, which incorporated established prognostic factors, was externally validated using independent data. Its performance was compared with that of the Nottingham Prognostic Index (NPI) and Adjuvant! Online.

Results

The number of positi

SUBMITTER: Campbell HE 

PROVIDER: S-EPMC2966633 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature