The transcription factor GATA-6 regulates pathological cardiac hypertrophy.

ABSTRACT:

Rationale

The transcriptional code that programs maladaptive cardiac hypertrophy involves the zinc finger-containing DNA binding factor GATA-4. The highly related transcription factor GATA-6 is also expressed in the adult heart, although its role in controlling the hypertrophic program is unknown.

Objective

To determine the role of GATA-6 in cardiac hypertrophy and homeostasis.

Methods and results

Here, we performed a cardiomyocyte-specific conditional gene targeting approach for Gata6, as well as a transgenic approach to overexpress GATA-6 in the mouse heart. Deletion of Gata6-loxP with Nkx2.5-cre produced late embryonic lethality with heart defects, whereas deletion with β-myosin heavy chain-cre (βMHC-cre) produced viable adults with >95% loss of GATA-6 protein in t

SUBMITTER: van Berlo JH 

PROVIDER: S-EPMC2967029 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature