Arsenic-related DNA copy-number alterations in lung squamous cell carcinomas.

ABSTRACT:

Background

Lung squamous cell carcinomas (SqCCs) occur at higher rates following arsenic exposure. Somatic DNA copy-number alterations (CNAs) are understood to be critical drivers in several tumour types. We have assembled a rare panel of lung tumours from a population with chronic arsenic exposure, including SqCC tumours from patients with no smoking history.

Methods

Fifty-two lung SqCCs were analysed by whole-genome tiling-set array comparative genomic hybridisation. Twenty-two were derived from arsenic-exposed patients from Northern Chile (10 never smokers and 12 smokers). Thirty additional cases were obtained for comparison from North American smokers without arsenic exposure. Twenty-two blood samples from healthy individuals from Northern Chile were examined to identify

SUBMITTER: Martinez VD 

PROVIDER: S-EPMC2967055 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature