MRI detection of VEGFR2 in vivo using a low molecular weight peptoid-(Gd)8-dendron for targeting.

ABSTRACT: The synthesis of a polylysine dendron containing eight GdDOTA units conjugated to a peptoid dimer known to have a high affinity for the vascular endothelial growth factor receptor 2 (VEGFR2) is described. This simple low molecular weight system with a molecular r(1) relaxivity of ∼48 mM(-1) s(-1) is shown to enhance MR images of tumors grown in mice in vivo.

SUBMITTER: De Leon-Rodriguez LM 

PROVIDER: S-EPMC2967214 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature