Assessing the quality of annotations in asthma gene expression experiments.

ABSTRACT:

Background

The amount of data deposited in the Gene Expression Omnibus (GEO) has expanded significantly. It is important to ensure that these data are properly annotated with clinical data and descriptions of experimental conditions so that they can be useful for future analysis. This study assesses the adequacy of documented asthma markers in GEO. Three objective measures (coverage, consistency and association) were used for evaluation of annotations contained in 17 asthma studies.

Results

There were 918 asthma samples with 20,640 annotated markers. Of these markers, only 10,419 had documented values (50% coverage). In one study carefully examined for consistency, there were discrepancies in drug name usage, with brand name and generic name used in different sections to ref

SUBMITTER: Lacson R 

PROVIDER: S-EPMC2967749 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature