Effects of fibrin-binding oligopeptide on osteopromotion in rabbit calvarial defects.

ABSTRACT:

Purpose

Fibronectin (FN) has been shown to stimulate bone regeneration in animal models. The aim of this study was to evaluate the capacity of bovine bone mineral coated with synthetic oligopeptides to enhance bone regeneration in rabbit calvarial defects.

Methods

Oligopeptides including fibrin-binding sequences of FN repeats were synthesized on the basis of primary and tertiary human plasma FN structures. Peptide coated and uncoated bone minerals were implanted into 10 mm calvarial defects in New Zealand white rabbits, and the animals were sacrificed at 4 or 8 weeks after surgery. After specimens were prepared, histologic examination and histomorphometric analysis were performed.

Results

At 4 weeks after surgery, the uncoated groups showed a limited amount of osteoid

SUBMITTER: Lee JA 

PROVIDER: S-EPMC2967808 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature