Evidence for significant overlap between common risk variants for Crohn's disease and ankylosing spondylitis.

ABSTRACT:

Background

A multicenter genome-wide association scan for Crohn's Disease (CD) has recently reported 40 CD susceptibility loci, including 29 novel ones (19 significant and 10 putative). To gain insight into the genetic overlap between CD and ankylosing spondylitis (AS), these markers were tested for association in AS patients.

Principal findings

Two previously established associations, namely with the MHC and IL23R loci, were confirmed. In addition, rs2872507, which maps to a locus associated with asthma and influences the expression of the ORMDL3 gene in lymphoblastoid cells, showed a significant association with AS (p = 0.03). In gut biopsies of AS and CD patients, ORMDL3 expression was not significantly different from controls and no correlation was found with the rs28725

SUBMITTER: Laukens D 

PROVIDER: S-EPMC2970560 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature