Assessment of clinical validity of a breast cancer risk model combining genetic and clinical information.

ABSTRACT:

Background

The Gail model is widely used for the assessment of risk of invasive breast cancer based on recognized clinical risk factors. In recent years, a substantial number of single-nucleotide polymorphisms (SNPs) associated with breast cancer risk have been identified. However, it remains unclear how to effectively integrate clinical and genetic risk factors for risk assessment.

Methods

Seven SNPs associated with breast cancer risk were selected from the literature and genotyped in white non-Hispanic women in a nested case-control cohort of 1664 case patients and 1636 control subjects within the Women's Health Initiative Clinical Trial. SNP risk scores were computed based on previously published odds ratios assuming a multiplicative model. Combined risk scores were calcu

SUBMITTER: Mealiffe ME 

PROVIDER: S-EPMC2970578 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature