The gastrointestinal nematode Trichostrongylus colubriformis down-regulates immune gene expression in migratory cells in afferent lymph.

ABSTRACT:

Background

Gastrointestinal nematode (GIN) infections are the predominant cause of economic losses in sheep. Infections are controlled almost exclusively by the use of anthelmintics which has lead to the selection of drug resistant nematode strains. An alternative control approach would be the induction of protective immunity to these parasites. This study exploits an ovine microarray biased towards immune genes, an artificially induced immunity model and the use of pseudo-afferent lymphatic cannulation to sample immune cells draining from the intestine, to investigate possible mechanisms involved in the development of immunity.

Results

During the development of immunity to, and a subsequent challenge infection with Trichostrongylus colubriformis, the transcript levels of 26

SUBMITTER: Knight JS 

PROVIDER: S-EPMC2970587 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature