Clinical implications of novel activating EGFR mutations in malignant peritoneal mesothelioma.

ABSTRACT:

Background

There is a paucity of information about the molecular perturbations involved in MPM tumor formation. We previously reported that EGFR-TK mutations in MPM were predictive of achieving optimal surgical cytoreduction, but the status of EGFR pathway activation potential of these mutations was not known. Here we present the mutant EGFR activating potential and the matured survival data of the EGFR mutant(mut+) relative to wild type EGFR(mut-) mesothelioma.

Methods

Twenty-nine patients were evaluated and their tumors were probed for mutations in the catalytic TK-domain. Twenty-five patients were treated with cytoreductive surgery and complete clinical data was available for comparison of the mut+ and mut- groups. A COS-7 cell expression model was used to determine mutat

SUBMITTER: Foster JM 

PROVIDER: S-EPMC2970593 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature