Transforming growth factor beta family expression at the bovine feto-maternal interface.

ABSTRACT:

Background

Endometrial remodelling is necessary for implantation in all mammalian species. The TGF beta super-family plays a crucial role in this event in humans and mice. However, the role of TGF beta super-family members during implantation is still unclear in ruminants. In the present study, the spacio-temporal expression of TGF beta super-family members including activin was explored in bovine trophoblasts and endometrial tissue during the peri-implantation period in order to elucidate whether it is essential for promoting cell proliferation at the implantation site.

Methods

Gene expression in the fetal membrane and endometrium of the gravid and non-gravid horn around Day 35 of gestation were analyzed with a custom-made oligo-microarray in cattle. The expression of activ

SUBMITTER: Sugawara K 

PROVIDER: S-EPMC2970602 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature