TSLP polymorphisms are associated with asthma in a sex-specific fashion.

ABSTRACT:

Background

Single nucleotide polymorphisms (SNPs) in thymic stromal lymphopoietin (TSLP) have been associated with IgE (in girls) and asthma (in general). We sought to determine whether TSLP SNPs are associated with asthma in a sex-specific fashion.

Methods

We conducted regular and sex-stratified analyses of association between SNPs in TSLP and asthma in families of children with asthma in Costa Rica. Significant findings were replicated in whites and African-American participants in the Childhood Asthma Management Program, in African-Americans in the Genomic Research on Asthma in the African Diaspora study, in whites and Hispanics in the Children's Health Study, and in whites in the Framingham Heart Study (FHS).

Main results

Two SNPs in TSLP (rs1837253 and rs2289276)

SUBMITTER: Hunninghake GM 

PROVIDER: S-EPMC2970693 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature