A candidate gene study of obstructive sleep apnea in European Americans and African Americans.

ABSTRACT:

Rationale

Obstructive sleep apnea (OSA) is hypothesized to be influenced by genes within pathways involved with obesity, craniofacial development, inflammation, and ventilatory control.

Objectives

We conducted the first candidate gene study of OSA using family data from European Americans and African Americans, selecting biologically plausible genes from within these pathways.

Methods

A total of 1,080 single nucleotide polymorphisms (SNPs) were genotyped in 729 African Americans and 505 SNPs were genotyped in 694 European Americans. Coding for SNPs additively, association testing on the apnea-hypopnea index (AHI) as a continuous trait, and OSA as a dichotomous trait (AHI ≥15) was conducted using methods that account for familial correlations in models adjusted for age

SUBMITTER: Larkin EK 

PROVIDER: S-EPMC2970865 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature