Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

3,19-Diacetyl-12-nitro-methyl-14-deoxy-andrographolide.

ABSTRACT: In the crystal of the title compound, C(24)H(33)NO(9), inter-molecular C-H⋯O hydrogen bonds link the mol-ecules.

SUBMITTER: Jia J

PROVIDER: S-EPMC2971007 | biostudies-literature | 2009 Oct

REPOSITORIES: biostudies-literature

ACCESS DATA

Json Xml

Publications

3,19-Diacetyl-12-nitro-methyl-14-deoxy-andrographolide.

Jia Juan J Yao Cheng C

Acta crystallographica. Section E, Structure reports online 20091031 Pt 11

In the crystal of the title compound, C(24)H(33)NO(9), inter-molecular C-H⋯O hydrogen bonds link the mol-ecules. ...[more]

PMID: 21578536

Similar Datasets

12-Nitro-methyl-14-deoxy-andro-graph-olide.

Project description:In the mol-ecule of the title compound {systematic name: 3-[2-(6-hydr-oxy-5-hydroxy-methyl-5,8a-dimethyl-2-methyl-ene-per-hydro-1-napth-yl)-1-(nitro-meth-yl)eth-yl]-2(4H)-furan-one}, C(21)H(31)NO(6), the cyclo-hexane rings have chair conformations. Intra-molecular O-H⋯O hydrogen bonding results in the formation of a six-membered non-planar ring with a twist conformation. In the crystal structure, inter-molecular O-H⋯O hydrogen bonds link the mol-ecules into infinite chains along the c axis.

| S-EPMC2961773 | biostudies-literature

Methyl 7-oxo-12-propyl-amino-13-nitro-deisopropyl-dehydro-abietate.

Project description:In the title compound, C(21)H(28)N(2)O(5) (systematic name: methyl 1,4a-dimethyl-7-nitro-9-oxo-6-propyl-amino-1,2,3,4,4a,9,10,10a-octa-hydro-phenanthrene-1-carboxyl-ate) the cyclo-hexane ring (A) and the central cyclo-hexene ring (B) exist at a trans ring junction, with the two methyl groups in the axial positions of the six-membered rings. Ring A has a chair conformation and ring B a half-chair conformation. An intra-molecular N-H?O hydrogen bond occurs. The crystal structure is stabilized by inter-molecular C-H?O and N-H?O inter-actions.

| S-EPMC2983386 | biostudies-literature

Methyl 3,5-dibromo-2-diacetyl-amino-benzoate.

Project description:The title methyl benzoate compound, C(12)H(11)Br(2)NO(4), consists of an ortho-substituted diacetyl-amino group and meta-substituted Br atoms. The crystal packing is stabilized by weak inter-molecular C-H⋯O inter-actions.

| S-EPMC3200936 | biostudies-literature

N,N'-Diacetyl-N'-[(4-nitro-phen-oxy)acetyl]acetohydrazide.

Project description:The asymmetric unit of the title compound, C(14)H(15)N(3)O(7), contains two independent mol-ecules which are linked into a pseudocentrosymmetric dimer by a π-π inter-action, as shown by the short distance of 3.722 (5) Å between the centroids of the benzene rings. An extensive network of weak inter-molecular C-H⋯O hydrogen bonds helps to stabilize the crystal packing.

| S-EPMC2968174 | biostudies-literature

Cytotoxic data of 14-deoxy-11, 12-didehydroandrographolide (14-DDA), double transfection and DDIT3 silencing data in T-47D breast carcinoma cells.

Project description:The data presented in this article are related to the research article entitled "14-deoxy-11,12-didehydroandrographolide induces DDIT3-dependent endoplasmic reticulum stress-mediated autophagy in T-47D breast carcinoma cells", which the mechanistic toxicology properties of 14-deoxy-11,12-didehydroandrographolide (14-DDA) were investigated (Tan et al., 2016 [1]). This article describes the derivation of cytotoxic parameters of 14-DDA, cell viability data after double transfection and DDIT3 silencing in T-47D cells.

| S-EPMC4857397 | biostudies-literature

15-deoxy-delta 12, 14-Prostaglandin J2 prevents reactive oxygen species generation and mitochondrial membrane depolarization induced by oxidative stress.

Project description:BackgroundWith the use of cultured human retinal pigment epithelial cells, we have previously described a number of cellular responses to oxidative stress caused by H2O2. We also demonstrated that the cytotoxicity caused by H2O2 could be prevented by the prostaglandin derivative, 15-deoxy-delta 12, 14-Prostaglandin J2 (15d-PGJ2).ResultsFurther characterization of the experimental system indicated that the half-life of H2O2 in cultures was ~1 hour. At a fixed H2O2 concentration, the cytotoxicity was dependent on the volume of H2O2 solution used in the culture, such that higher volume caused more cytotoxicity. Most cells were committed to die if the culture was treated for 2 hours with a cytotoxic concentration of H2O2. The prostaglandin derivative, 15d-PGJ2, could prevent oxidative damage caused by t-butyl hydroperoxide, in addition to H2O2. Further studies indicated that both H2O2 and tBH caused an increase in reactive oxygen species and depolarization of mitochondrial membrane potential. Pretreatment of cells with 1 microM 15d-PGJ2 led to a modest decrease in reactive oxygen species generation, and a significant restoration of mitochondrial membrane potential.ConclusionThis agent may be used in the future as a pharmacological tool for preventing cellular damage caused by oxidative stress.

| S-EPMC446193 | biostudies-literature

Fabrication, characterization, <i>in vitro</i> drug release and glucose uptake activity of 14-deoxy, 11, 12-didehydroandrographolide loaded polycaprolactone nanoparticles.

Project description:Biodegradable polymer based novel drug delivery systems brought a considerable attention in enhancing the therapeutic efficacy and bioavailability of various drugs. 14-deoxy 11, 12-didehydro andrographolide (poorly water soluble compound) loaded polycaprolactone (nano-DDA) was synthesized using the solvent evaporation technique. Nano-DDA was characterized by scanning electron microscopy (SEM) and dynamic light scattering (DLS) studies. Fourier Transform InfraRed Spectroscopy (FTIR) was used to investigate the structural interaction between the drug and the polymer. Functional characterization of the formulation was determined using drug content, cellular uptake and in vitro drug release. 2-deoxy-D-[1-3H] glucose uptake assay was carried out to assess the antidiabetic potential of nano-DDA in L6 myotubes. The nano-DDA displayed spherical shape with a smooth surface (252.898 nm diameter), zeta potential, encapsulation and loading efficiencies of -38.9 mV, 91.98 ± 0.13% and 15.09 ± 0.18% respectively. No structural alteration between the drug and the polymer was evidenced (FTIR analysis). Confocal microscopy studies with rhodamine 123 loaded polycaprolactone nanoparticles (Rh123-PCL NPs) revealed the internalization of Rh123-PCL NPs in a time dependent manner in L6 myoblasts. A dose dependent increase in glucose uptake was observed for nano-DDA with a maximal uptake of 108.54 ± 1.42% at 100 nM on L6 myotubes, thereby proving its anti-diabetic efficacy. A biphasic pattern of in vitro drug release demonstrated an initial burst release at 24 h followed by a sustained release for up to 11 days. To conclude, our results revealed that nano-DDA formulation can be a potent candidate for antidiabetic drug delivery.

| S-EPMC7032135 | biostudies-literature

6-Ethyl-N-methyl-3-nitro-4-nitro-methyl-4H-chromen-2-amine.

Project description:In the title compound, C(13)H(15)N(3)O(5), the O and N atoms of the nitro-methyl group and the methyl C atom of the ethyl group are disordered over two sets of sites with refined occupancies of 0.629 (7):0.371 (7) and 0.533 (8):0.467 (8), respectively. The dihydro-pyran ring has an extremely flattened conformation. An intra-molecular N-H⋯O hydrogen bond occurs. In the crystal, pairs of N-H⋯O hydrogen bonds link mol-ecules, forming inversion dimers. In addition, weak inter-molecular C-H⋯O hydrogen bonds are also present.

| S-EPMC3254519 | biostudies-literature

6,8-Dichloro-N-methyl-3-nitro-4-nitro-methyl-4H-chromen-2-amine.

Project description:In the title compound, C(11)H(9)Cl(2)N(3)O(5), the dihydro-pyran ring adopts a near-half-chair conformation. The benzene ring makes a torsion angle of 5.02 (5)° with the dihydro-pyran ring. Adjacent mol-ecules are inter-linked through inter-molecular C-H⋯O, N-H⋯O and C-Cl⋯π [3.4743 (9) Å] inter-actions. The inter-molecular N-H⋯O hydrogen bond generates an R(2) (2)(12) motif, which is observed to contribute to the crystal packing stability. Moreover, the mol-ecular structure displays an S(6) motif formed by intra-molecular N-H⋯O hydrogen bonding.

| S-EPMC3099939 | biostudies-literature

4-(3,4-Diacetyl-5-methyl-1H-pyrazol-1-yl)benzene-sulfonamide.

Project description:In the title mol-ecule, C(14)H(15)N(3)O(4)S, the pyrazole ring is aligned at a dihedral angle of 55.5 (1)° with respect to the benzene ring; the mean planes of the acetyl substituents are twisted by 13.4 (3) and 30.1 (3)° with respect to the pyrazole ring. Inter-molecular classical N-H⋯O and weak C-H⋯O hydrogen bonding links the mol-ecules, forming a three-dimensional network architecture in the crystal structure.

| S-EPMC3052070 | biostudies-literature

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data