Characterizing molecular adaptation: a hierarchical approach to assess the selective influence of amino acid properties.

ABSTRACT:

Motivation

A number of methods for detecting positive selection in protein coding DNA sequences are based on whether each site/region has a non-synonymous to synonymous substitution rates ratio ω greater than one. However, a site/region may show a relatively large number of non-synonymous mutations that conserve a particular property. Recent methods have proposed to consider as evidence for molecular adaptations how conserving, or radically different, non-synonymous mutations are with respect to some key amino acid properties. While such methods have been useful in providing a qualitative assessment of molecular adaptation, they rely on independent statistical analyses for each amino acid property and typically do not properly adjust for multiple comparisons when selection needs to

SUBMITTER: Datta S 

PROVIDER: S-EPMC2971574 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature