Diet-induced obesity in zebrafish shares common pathophysiological pathways with mammalian obesity.

ABSTRACT:

Background

Obesity is a multifactorial disorder influenced by genetic and environmental factors. Animal models of obesity are required to help us understand the signaling pathways underlying this condition. Zebrafish possess many structural and functional similarities with humans and have been used to model various human diseases, including a genetic model of obesity. The purpose of this study was to establish a zebrafish model of diet-induced obesity (DIO).

Results

Zebrafish were assigned into two dietary groups. One group of zebrafish was overfed with Artemia (60 mg dry weight/day/fish), a living prey consisting of a relatively high amount of fat. The other group of zebrafish was fed with Artemia sufficient to meet their energy requirements (5 mg dry weight/day/fish). Zebr

SUBMITTER: Oka T 

PROVIDER: S-EPMC2972245 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature